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Jumat, 01 Juni 2012

In Australia, Where Not To Have A Heart Attack

Main Category: Cardiovascular / Cardiology
Also Included In: Public Health
Article Date: 01 Jun 2012 - 0:00 PDT

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Every single town in Australia has been rated on its proximity to cardiac care, before and after a heart attack, in a new report published in Circulation and headed by Queensland University of Technology (QUT).

Associate Professor Robyn Clark, from QUT's School of Nursing, led a national research team for the seven-year multi-disciplinary project, entitled the Cardiac Accessibility and Remoteness Index for Australia (Cardiac ARIA), with funding from an Australian Research Council Linkage Grant and linkage partner AlphaPharm Pty Ltd.

The index, developed by cardiology professionals and geographers, informs residents and health professionals on what level of emergency and preventative care is available in their neighbourhood in the potentially life-threatening event of a heart attack and when they return home after a cardiac event.

Professor Clark said the project found 71 per cent of Australians lived in Cardiac ARIA "1A" locations, which have specialist hospital care and four types of aftercare within one hour's drive.

However, she said, only 68 per cent of people over 65 years of age and 40 per cent of Indigenous people lived within 1A locations.

"The first 60 minutes of experiencing symptoms of a heart attack or any cardiac event is the 'golden hour' in which to receive treatment and achieve the best recovery results possible," she said.

"It is also the maximum length of time people seem willing to travel to get to services that help prevent future secondary attacks after they return home, which occurs in 50 per cent of cases."

Professor Clark said each location was given a numeric/alpha rating, where the number related to proximity of emergency cardiac care, and the alphabetic letter referred to accessibility of services which helped prevent a secondary cardiac event.

The Cardiac ARIA index for 20,387 Australian locations can be found here*.

The numeric index ranged from 1 (access to principal referral centre with cardiac catheterization service up to one hour away) to 8 (no ambulance service, more than 3 hours to a medical facility, with air transport required). The alphabetic index ranged from A (all four aftercare services - family doctor, pharmacy, cardiac rehabilitation, and pathology services - available within a one hour drive) to E (no services available within one hour).

Professor Clark said no matter how near or far a person lived from treatment, the most important factor in surviving a heart attack was to recognise it and seek help as soon as possible and for rural and remote communities to have systems in place to access specialist cardiac care even if it is virtual, using communication technology.

"This list may encourage people to react early if they know how far they are from cardiac care," she said.

"It may also help health professionals make the best decision on which type of emergency care to use and for communities to ensure efficient clinical pathways can be activated for rapid access to specialist cardiac care.

"For example, a person may be close to a regional medical centre where clot-busting drugs (called thrombolytic agents) can be administered, but within an hour's ambulance drive from a cardiac catheterization service, where stents (tiny wire mesh tubes which prop open arteries) can be inserted, so a decision needs to be made whether to get nearby help, or to re-route to the specialist cardiac care."

Professor Clark said heart attacks were caused when build ups of fatty deposits, called plaque, clotted the arteries which fed the heart muscle and prevented blood flow.

She said emergency cardiac events also included cardiac arrest, life-threatening arrhythmias, acute coronary syndromes and acute decompensating heart failure. They were indicated by symptoms such as chest pain, collapse, loss of consciousness, severe shortness of breath, fainting and sustained palpitations with light-headedness.

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our cardiovascular / cardiology section for the latest news on this subject.
Please use one of the following formats to cite this article in your essay, paper or report:

MLA

Queensland University of Technology. "In Australia, Where Not To Have A Heart Attack." Medical News Today. MediLexicon, Intl., 1 Jun. 2012. Web.
1 Jun. 2012.


APA
Queensland University of Technology. (2012, June 1). "In Australia, Where Not To Have A Heart Attack." Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/246021.php.

Please note: If no author information is provided, the source is cited instead.



'In Australia, Where Not To Have A Heart Attack'

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Increased Risk Of Heart Rhythm Dysfunction, Sudden Death Caused By Genetic Variant

Main Category: Heart Disease
Also Included In: Genetics;  Cardiovascular / Cardiology
Article Date: 01 Jun 2012 - 0:00 PDT

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Cardiovascular researchers at the University of Cincinnati (UC) have identified a genetic variant in a cardiac protein that can be linked to heart rhythm dysfunction.

This is the first genetic variant in a calcium-binding protein (histidine-rich calcium binding protein) found to be associated with ventricular arrhythmias and sudden cardiac death in dilated cardiomyopathy patients, opening up new possibilities for treatment.

Dilated cardiomyopathy is a condition in which the heart becomes weakened and enlarged and cannot pump blood efficiently.

These findings were presented for the first time at the International Society of Heart Research's Pathology and Treatment of Heart Failure meeting in Banff, Alberta, held May 27 through May 31, 2012.

The team led by Vivek Singh, PhD, a research scientist under the direction of Litsa Kranias, PhD, in the department of pharmacology and cell biophysics at UC, says that sudden cardiac death is a risk for patients with heart failure who are carriers of this variant in the histidine-rich calcium-binding protein because the calcium inside their heart cells is not properly controlled, possibly leading to the development of arrhythmias.

"The histidine-rich calcium-binding protein (HRC) is a regulator of calcium uptake and release in the sarcoplasmic reticulum, a network of tubes and sacs in heart muscle fibers that plays an important role in heart contraction and relaxation by releasing and storing calcium ions," Singh says.

"Recently, our group at UC and Athens, Greece, identified a genetic variant in HRC, named Ser96Ala, which showed a significant association with worsening ventricular arrhythmias and sudden cardiac death in a group of patients with idiopathic dilated cardiomyopathy. In this study, our team characterized the mechanisms and pathways that link the HRC variant with arrhythmias causing sudden death."

Researchers first generated animal models with cardiac-specific expression of the human normal (S96S) or altered (A96A) HRC.

"Unexpectedly, we found that contractility of heart cells significantly decreased with disturbed calcium regulation in A96A hearts when compared with S96S hearts," Singh says. "In addition, A96A heart cells showed more arrhythmic behavior under stress conditions."

Singh says this data could eventually provide new insights into pathways that control calcium regulation, leading to the development of new clinical interventions.

"Our results showed that the human HRC mutant model displayed altered intracellular calcium (Ca2+) handling, associated with slowed Ca2+ uptake and increased Ca2+ leak, which may promote arrhythmias under stress," Singh says. "These new findings are important because we can use this information to help develop new methods of screening human patients and preventing arrhythmia development in the carriers."

Article adapted by Medical News Today from original press release. Click 'references' tab above for source.
Visit our heart disease section for the latest news on this subject.
This study was funded by an American Heart Association Fellowship Award and the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.
University of Cincinnati Academic Health Center
Please use one of the following formats to cite this article in your essay, paper or report:

MLA

University of Cincinnati Academic Health Center. "Increased Risk Of Heart Rhythm Dysfunction, Sudden Death Caused By Genetic Variant." Medical News Today. MediLexicon, Intl., 1 Jun. 2012. Web.
1 Jun. 2012.


APA
University of Cincinnati Academic Health Center. (2012, June 1). "Increased Risk Of Heart Rhythm Dysfunction, Sudden Death Caused By Genetic Variant." Medical News Today. Retrieved from
http://www.medicalnewstoday.com/releases/246020.php.

Please note: If no author information is provided, the source is cited instead.


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Note: Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a health care professional. For more information, please read our terms and conditions.


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